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Published on: December 10, 2016
Effect of deoxycholate, amphotericin B and fongizone on transmissible gastroenteritis coronavirus
T D Nguyen1, E Bottreau1, J M Aynaud1
1INRA, Laboratoire de Pathologie Porcine, 37380 Nouzilly (France).
Abstract:
At a concentration of 2 μg/ml, neither amphotericin B nor deoxycholate had an inactivating effect upon transmissible gastroenteritis Coronavirus in-fectivity. However, amphothericin B stimulated plaque formatin in agarose and facilitated the entry of viral RNA into swine testis cells. The combination of amphotericin B + deoxycholate inactivated virus infectivity and induced a decrease in plaque diameter. Finally, in the presence of these agents, the production of infectious virus and interferon was unchanged.
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