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Marc S Horwitz1, Nora Sarvetnick1

  • 1Département de neuropharmacologie, The Scripps Research Institute, 10550 N Torrey Pines road, La Jolla, CA 92037, États-Unis USA.

Annales De L'Institut Pasteur. Actualites
|April 15, 2020
PubMed
Summary

Viruses can trigger autoimmune diseases by mimicking molecules or causing inflammation, leading to immune system errors. These viral triggers are crucial in initiating and potentially worsening autoimmune conditions.

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Area of Science:

  • Virology
  • Immunology
  • Autoimmune Diseases

Context:

  • Viruses are increasingly linked to the development of autoimmune diseases.
  • Understanding the mechanisms by which viral infections initiate autoimmunity is crucial for therapeutic development.

Purpose:

  • To discuss the primary mechanisms by which viruses may initiate autoimmune diseases.
  • To explore the roles of molecular mimicry and inflammation in viral-induced autoimmunity.
  • To consider the potential role of viruses in the chronicity of autoimmune conditions.

Summary:

  • Viral infections are associated with autoimmune diseases through mechanisms like molecular mimicry and inflammation.
  • Molecular mimicry involves viral proteins resembling self-antigens, leading to immune cross-reactivity.
  • Local inflammation during viral infection can activate immune cells and break self-tolerance.

Impact:

  • Elucidates key viral mechanisms contributing to autoimmune disease initiation.
  • Provides a foundation for understanding virus-driven autoimmunity.
  • Suggests potential therapeutic targets for preventing or managing autoimmune diseases triggered by infections.

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