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Updated: Dec 24, 2025

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds
Published on: October 29, 2015
[Emergent viruses and/or repeated threats]
1Laboratoire de Virologie Lyon Est, CNR des entérovirus & CNR des virus influenza région sud, UMR CNRS 5537, Domaine Rockefeller, 69373 Lyon cedex 08.
Abstract:
Emergent viruses have attracted attention during years 2003 and 2004. Ancient fears have reappeared regarding pathogenic agents, capable to result in epidemics with high mortality rates. Such events constitute really repeated threats. The analysis of mechanisms permitting emergence of these viruses has shown that they are not random phenomenons, but they result from accumulated factors leading to transmission from animals to men. Several modes of transmission of infection include: either direct transmission, or by intermediate vectors (mosquitoes, ticks and other (mammals) animals). Convergence of ecologic, economic and epidemiologic factors confer to the epidemics potential ability do spread widely. With the development of surveillance networks and improvement in diagnostic technologies, these "new" viruses are better identified. Recent occurrence of SARS and of the avian influenza are best examples of such experiences.
Insights
Emergent viruses, like SARS and avian flu, pose repeated threats due to factors enabling animal-to-human transmission. Understanding these viral emergence mechanisms is crucial for public health preparedness.
Area of Science:
- Virology
- Epidemiology
- Public Health
Context:
- Emerging viruses pose significant global health risks, as evidenced by recent epidemics.
- Factors contributing to viral emergence and transmission are of increasing concern.
- Historical fears of pathogenic agents capable of causing high-mortality epidemics have resurfaced.
Purpose:
- To analyze the mechanisms behind viral emergence.
- To understand the factors leading to zoonotic transmission.
- To highlight the role of ecological, economic, and epidemiological factors in epidemic spread.
Summary:
- Viral emergence is not random but results from accumulated factors facilitating animal-to-human transmission.
- Transmission routes include direct contact and intermediate vectors like mosquitoes, ticks, and mammals.
- Ecological, economic, and epidemiological factors converge, enabling widespread epidemic potential.
Impact:
- Improved surveillance networks and diagnostic technologies enhance the identification of emerging viruses.
- Recent outbreaks such as SARS and avian influenza underscore the importance of studying viral emergence.
- This research informs strategies for preventing and managing future epidemic threats.
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