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Updated: Dec 24, 2025
06:38
An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
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[New therapies against HCV].
1Unité de Recherche Risques Microbiens (EA4655), Université de Caen Normandie, Esplanade de la Paix, F-14000 Caen.
Revue Francophone Des Laboratoires : RFL
|April 15, 2020
Summary
Human coronaviruses (HCoV) cause mild respiratory illness but can lead to severe infections in vulnerable groups. Monitoring these viruses is crucial due to their potential for emergence from animal reservoirs.
Area of Science:
- Virology
- Respiratory Infections
Context:
- Human coronaviruses (HCoV) are single-stranded RNA viruses.
- Four classical/novel HCoVs circulate seasonally, causing mild respiratory infections.
- HCoVs account for 2-7% of respiratory infection hospitalizations.
Purpose:
- To differentiate between common and emerging HCoVs.
- To highlight the increased severity and epidemic potential of SARS-CoV and MERS-CoV.
- To emphasize the need for monitoring HCoVs due to zoonotic potential.
Summary:
- Classical HCoVs cause mild respiratory illness, but affect susceptible populations (children, elderly, immunocompromised) more severely.
- Emerging HCoVs like SARS-CoV and MERS-CoV present greater health risks with higher epidemic potential.
- HCoVs are routinely detected using molecular biology tools alongside other respiratory viruses.
Impact:
- HCoVs represent a significant burden on healthcare systems, especially in hospitalized patients.
- Understanding HCoV circulation and severity is vital for public health surveillance.
- Continuous monitoring is essential to detect and respond to potential HCoV outbreaks from animal sources.
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