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Updated: Dec 24, 2025

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
Published on: May 5, 2014
Development of Drugs Based on High-Polymeric Double-Stranded RNA for Antiviral and Antitumor Therapy
E D Danilenko1, A O Belkina1, G M Sysoeva1
1Institute of Medical Biotechnology, State Research Center of Virology and Biotechnology (SRC VB) "Vector", Khimzavodskaya ul. 9, 633010 Berdsk, Novosibirsk region Russia.
Abstract:
Abstract-The review summarizes literature data on the development of drugs based on natural and synthetic high-polymeric double-stranded RNA (dsRNA), their antiviral, immunoadjuvant, and antitumor properties. Special attention is paid to cell receptors responding to exogenous dsRNA, pathways of dsRNA-dependent antiviral reaction, ability of dsRNA to inhibit growth and induce apoptosis of malignant cells. It has been shown that enhancing the innate immune response with dsRNA can be an effective component in improving methods for treating and preventing infectious and cancer diseases. The further use of dsRNA for the correction of pathological processes of different origin is discussed.
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