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Updated: Dec 24, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Common problems associated with the microbial productions of aromatic compounds and corresponding metabolic
Meijie Li1, Changqing Liu2, Jianming Yang3
1Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 135 Songling Road, Qingdao 266101, China; Energy-Rich Compound Production by Photosynthetic Carbon Fixation Research Center, College of Life Sciences, Qingdao Agricultural University, No. 700 Changchen Road, Qingdao 266109, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Abstract:
Recent progress in metabolic engineering and synthetic biology has enabled the production of valuable chemicals in microbial cell factories from renewable feedstocks. High value-added aromatic compounds, most of which are traditionally chemically synthesized from petroleum-derived feedstocks, represent a large class of chemicals with industrial significance. The microbial biosynthesis of aromatic compounds has been studied for decades, and varying yields have been achieved for different aromatic compounds. In this review, we describe the common problems associated with the microbial biosynthesis of diverse aromatic compounds and summarize the corresponding metabolic engineering strategies for resolving these problems. In addition, future perspectives on the microbial production of aromatic compounds are discussed.
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