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Apamin from bee venom suppresses inflammation in a murine model of gouty arthritis
Yun Mi Lee1, Soo-Na Cho2, Eunjung Son1
1Herbal Medicine Research Division, Korea Institute of Oriental Medicine, Daejeon, 34054, South Korea.
Ethnopharmacological Relevance:
Bee venom (BV) has been used for the treatment of inflammatory diseases, such as rheumatoid arthritis, and for the relief of pain in traditional oriental medicine.
Aim Of Study:
The aim of this study was to determine the anti-inflammatory effect of BV on monosodium urate (MSU)-induced gouty arthritis in a mouse model.
Materials And Methods:
To develop a mouse model of acute gouty arthritis, 4 mg 50 μL-1 of MSU crystal suspension was injected intradermally into the right paw. After MSU crystal injection, we evaluated inflammatory cytokine production in mice of the BV-treated (0.5 and 1 mg kg-1 body weight) and apamin (APM)-treated (0.5 and 1 mg kg-1 body weight) groups. The positive control group was administered a colchicine (1 mg kg-1 body weight) injection with MSU crystals.
Results:
BV and APM treatment suppressed inflammatory paw edema in MSU-administered mice. It also exerted anti-inflammatory effects in mice with gouty arthritis by inhibiting proinflammatory cytokine production and inflammasome formation. Interestingly, MSU crystal formation was decreased by BV and APM treatment.
Conclusions:
These results suggest that the APM from BV might be useful for the treatment of gouty arthritis due to its anti-inflammatory activities.
