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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Non-Canonical Wnt Signaling Pathways01:41

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Atherosclerosis I: Introduction01:30

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Notch Signaling Pathway03:14

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Inflammation

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Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Related Experiment Video

Updated: Dec 24, 2025

Modeling Paracrine Noncanonical Wnt Signaling In Vitro
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atherosclerosis: gone with the Wnt?

Philippe Boucher1, Rachel L Matz1, Jérôme Terrand1

  • 1CNRS, UMR 7021, University of Strasbourg, 67401, Illkirch, France.

Atherosclerosis
|April 15, 2020
PubMed
Summary

Wnt signaling influences cellular cholesterol accumulation, a key factor in atherosclerosis. Understanding this pathway offers new therapeutic strategies for cardiovascular disease.

Area of Science:

  • Cardiovascular Biology
  • Cellular Metabolism
  • Molecular Signaling

Background:

  • Atherosclerosis is a leading cause of cardiovascular disease, characterized by cholesterol accumulation in arterial cells.
  • Foam cell formation, driven by modified low-density lipoprotein uptake, is central to atherosclerotic lesion development.
  • Recent research has illuminated early lesion formation, cholesterol transport, and vascular inflammation.

Purpose of the Study:

  • To review the role of Wnt signaling in regulating cellular cholesterol accumulation.
  • To explore Wnt signaling's impact on pathways limiting cholesterol buildup.
  • To highlight Wnt signaling's potential in atherosclerotic disease development and progression.

Main Methods:

  • Literature review focusing on Wnt signaling and cholesterol metabolism.
Keywords:
Wnt, cholesterol trafficking, lysosomal function, atherosclerosis, endocytosis

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  • Analysis of Wnt signaling's effects on lysosomal function and related pathways.
  • Examination of Wnt signaling's influence in arterial wall cells (smooth muscle cells, endothelial cells, macrophages).

    • Main Results:

    • Wnt signaling affects lysosomal function, a key regulator of cellular cholesterol levels.
    • This signaling pathway impacts pathways that limit cholesterol accumulation in various cell types.
    • Wnt signaling plays a significant role in the development and progression of atherosclerosis.

    Conclusions:

    • Wnt signaling is an underappreciated factor in atherosclerosis pathogenesis.
    • Targeting Wnt signaling pathways may offer novel therapeutic avenues for cardiovascular disease.
    • Further research into Wnt signaling's role in cholesterol homeostasis is warranted.