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Related Concept Videos

Electroconvulsive Therapy01:30

Electroconvulsive Therapy

633
Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
633

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Related Experiment Video

Updated: Dec 24, 2025

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
09:07

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins

Published on: August 15, 2017

12.5K

Structural changes induced by electroconvulsive therapy are associated with clinical outcome.

Peter C R Mulders1, Alberto Llera2, Christian F Beckmann3

  • 1Department of Psychiatry, Radboud University Medical Center, Nijmegen, the Netherlands; Donders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging, Nijmegen, the Netherlands.

Brain Stimulation
|April 15, 2020
PubMed
Summary

Structural brain changes in specific areas predict response to electroconvulsive therapy (ECT) for major depressive disorder. This research identifies key brain regions related to ECT

Keywords:
DepressionElectroconvulsive therapyMRIMajor depressive disorder

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Last Updated: Dec 24, 2025

Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins
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Area of Science:

  • Neuroimaging
  • Psychiatry
  • Brain Anatomy

Background:

  • Electroconvulsive therapy (ECT) is a highly effective treatment for major depressive disorder.
  • Understanding the neurobiological underpinnings of ECT's efficacy is crucial for advancing antidepressant research.

Purpose of the Study:

  • To investigate the relationship between structural brain volumetric changes and clinical response to ECT.
  • To identify specific brain regions associated with treatment response and electrode placement (unilateral vs. bilateral).

Main Methods:

  • Longitudinal structural magnetic resonance imaging (MRI) data from 192 subjects were analyzed.
  • Recursive feature elimination was used to identify relevant volumetric changes for classifying treatment response.
  • Linear classifiers were trained to predict response and electrode placement based on structural data.

Main Results:

  • A pattern of structural changes in cortical midline, striatal, and lateral prefrontal areas accurately predicted ECT responders (75% accuracy).
  • Left-sided mediotemporal structural changes distinguished unilateral from bilateral electrode placement (81% accuracy).

Conclusions:

  • Multivariate analysis demonstrates that structural brain changes are relevant to clinical outcomes in ECT.
  • The identified pattern of structural change differs from previously studied mediotemporal regions.