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Thrombo-Inflammation in Cardiovascular Disease: An Expert Consensus Document from the Third Maastricht Consensus

Elisa d'Alessandro1, Christian Becker2, Wolfgang Bergmeier3

  • 1Laboratory for Clinical Thrombosis and Hemostasis, Department of Biochemistry and Internal Medicine and Thrombosis Expert Center, Maastricht University Medical Center and CARIM School for Cardiovascular Diseases, Maastricht, The Netherlands.

Thrombosis and Haemostasis
|April 15, 2020
PubMed

Insights

Thrombo-inflammation, the link between blood clotting and inflammation, is key in cardiovascular diseases. Experts recommend strategies for managing conditions like heart attack and stroke.

Area of Science:

  • Cardiovascular Science
  • Hematology
  • Immunology

Background:

  • Thrombo-inflammation, the interplay of coagulation and inflammation, is central to cardiovascular diseases.
  • The Maastricht Consensus Conference convened experts to discuss its role in myocardial infarction, stroke, and peripheral artery disease.

Framework:

  • Expert opinions and consensus on endothelial cell barrier challenges.
  • Focus on circulating cells (platelets, neutrophils, NETs) in thrombo-inflammation.
  • Discussion of procoagulant mechanisms and arterial vascular changes in atherogenesis.

Implementation:

  • Strategies for attenuating atherosclerosis and ischemia/reperfusion injury.
  • Management of patients with arterial vascular disease.
  • Understanding venous thrombosis pathogenesis and long-term consequences.

Implications:

  • Advances understanding of cardiovascular disease etiology and diagnostics.
  • Provides expert recommendations for clinical management.
  • Highlights critical areas for future research in thrombosis and inflammation.

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