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Nanoparticles Based on Novel Carbohydrate-Functionalized Polymers.

Cláudia D Raposo1, Cristiano A Conceição1, M Teresa Barros1

  • 1LAQV-REQUIMTE, Department of Chemistry, NOVA School of Science and Technology, Universidade NOVA de Lisboa, 2829-516 Caparica, Portugal.

Molecules (Basel, Switzerland)
|April 16, 2020
PubMed
Summary

Functionalized poly(lactic-co-glycolic acid) (PLGA) nanoparticles were successfully prepared for drug delivery. Poly(ethylene glycol) (PEG) derivatives, however, formed films, indicating challenges in nanoparticle formation.

Keywords:
PEGPLGAcoumarinsdrug delivery systemsgalactoseglucosemannosepolymeric nanoparticlesthymidine

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery

Background:

  • Polymeric nanoparticles are crucial for advanced healthcare drug delivery systems.
  • Poly(lactic-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) are versatile polymers for nanoparticle matrices.
  • Functionalization with specific moieties enhances nanoparticle targeting and efficacy.

Purpose of the Study:

  • To functionalize PLGA and PEG polymers with coumarin and carbohydrate groups (thymidine, glucose, galactose, mannose).
  • To prepare and characterize functionalized nanoparticles for potential drug delivery applications.
  • To investigate the impact of functionalization on nanoparticle formation and properties.

Main Methods:

  • Utilized a single oil-in-water emulsion method for nanoparticle preparation.
  • Functionalized PLGA and PEG polymers with coumarin and various carbohydrate moieties.
  • Characterized nanoparticle size, polydispersity index, and zeta potential.

Main Results:

  • Successfully prepared functionalized PLGA nanoparticles with sizes ranging from 114-289 nm.
  • Achieved nanoparticles with smooth surfaces, low polydispersity, and zeta potentials between -28.2 and -56.0 mV.
  • PEG derivatives resulted in film formation instead of nanoparticles due to limited hydrophobic core size.

Conclusions:

  • Functionalized PLGA nanoparticles are viable for drug delivery systems.
  • The methodology is effective for creating targeted nanoparticles with controlled characteristics.
  • Challenges exist in forming PEG nanoparticles with the current approach, requiring further optimization.