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Inhibition of ConA-induced proliferative response in human lymphocytes by podophyllotoxin and a detergent, Tween80
B Månsson1, P Geborek, T Hallberg
1Department of Rheumatology, University Hospital, Lund, Sweden.
Clinical and Experimental Rheumatology
|October 1, 1988
Abstract:
Podophyllotoxin (CPH86), at concentrations of 5 ng/ml or more, inhibited [3H]-thymidine uptake of ConA-induced proliferation of human peripheral mononuclear blood cells. Tween80, the detergent included in the anti-inflammatory drug Proresid, containing podophyllum lignan derivatives, also inhibited lymphocyte proliferation in a dose-dependent manner. Combination of the two drugs did not, or did only weakly, potentiate the inhibitory effect of each drug.