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Drug induced lung toxicity by nitrofurantoin
Casopis Lekaru Ceskych
|April 16, 2020
Summary
Nitrofurantoin (FUR) can cause lung toxicity, identified through patient history and CT scans. Stopping FUR treatment led to significant lung improvement without needing steroids.
Area of Science:
- Pulmonology
- Pharmacology
- Radiology
Background:
- Nitrofurantoin is a common antibiotic used for urinary tract infections.
- Drug-induced lung disease is a potential adverse effect of various medications, including nitrofurantoin.
Observation:
- A patient presented with extensive interstitial changes on high-resolution computed tomography (HRCT) scans.
- These changes were noted before the initiation of nitrofurantoin treatment.
Findings:
- The diagnosis of nitrofurantoin lung toxicity was established through clinical history and imaging.
- Negative microbiology and autoantibody screening supported the diagnosis.
- Complete regression of interstitial lung changes was observed after discontinuing nitrofurantoin therapy.
Implications:
- This case highlights the importance of considering drug-induced lung toxicity in patients on nitrofurantoin.
- Early diagnosis and withdrawal of the offending agent can lead to favorable outcomes.
- Avoidance of corticosteroids or immunosuppressants may be possible with prompt management.
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