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Updated: Dec 24, 2025
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Antibiotics and cement: what I need to know?
Antonio V Pellegrini1, Virginia Suardi2
1Centre of Reconstructive Surgery and Osteo-Articular Infections (C.R.I.O), IRCCS Galeazzi Orthopaedic Institute, Milan, Italy.
Summary
This systematic review summarizes clinical evidence for antibiotic-loaded bone cement (ALBC), addressing common concerns and analyzing associated costs for orthopedic applications.
Area of Science:
- Orthopedics
- Infectious Disease Management
- Biomaterials Science
Background:
- Antibiotic-loaded bone cement (ALBC) is widely used for preventing and treating bone infections.
- Concerns exist regarding the clinical efficacy, safety, and economic impact of ALBC.
- A comprehensive understanding of the existing evidence is crucial for optimizing its use.
Purpose of the Study:
- To systematically review the clinical evidence supporting the use of antibiotic-loaded bone cement (ALBC).
- To identify and analyze prevalent concerns associated with ALBC application.
- To evaluate the cost-effectiveness of ALBC in orthopedic surgery.
Main Methods:
- Systematic literature search across major medical databases.
- Inclusion of studies reporting clinical outcomes, adverse events, and cost data for ALBC.
- Quality assessment of included studies to ensure reliable evidence synthesis.
Main Results:
- The review synthesizes current clinical data on ALBC efficacy and safety profiles.
- Identified key concerns regarding antibiotic resistance, elution kinetics, and surgical complications.
- Analysis of ALBC cost-effectiveness in comparison to alternative infection management strategies.
Conclusions:
- Antibiotic-loaded bone cement (ALBC) demonstrates significant clinical utility but requires careful consideration of potential drawbacks.
- Addressing concerns and optimizing cost-effectiveness are key for maximizing ALBC benefits.
- Further research is warranted to refine ALBC protocols and expand its evidence base.
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