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Nanonization techniques to overcome poor water-solubility with drugs
Flávia Lidiane Oliveira Da Silva1, Maria Betânia De Freitas Marques1,2, Kelly Cristina Kato1
1Department of Pharmacy, Faculty of Biological and Health Sciences, Federal University of Jequitinhonha and Mucuri Valleys , Diamantina, Brazil.
Expert Opinion on Drug Discovery
|April 16, 2020
Summary
Nanonization of drugs enhances solubility and bioavailability for poorly water-soluble medications. This review explores nanomedicine strategies, including lipid-based nanosystems, to overcome pharmaceutical development challenges.
Area of Science:
- Pharmaceutical Science
- Nanotechnology
- Drug Delivery
Background:
- Many therapeutic drugs exhibit poor water-solubility, hindering their dissolution rate and oral bioavailability.
- This presents a significant challenge in pharmaceutical development and formulation.
- Nanonization, reducing drug particles to the nanoscale, is a key strategy to address this issue.
Purpose of the Study:
- To review the consequences of poor water-solubility in drug development.
- To explore strategies for increasing the solubility of poorly water-soluble drugs.
- To examine the role of drug nanoparticles and nanocarriers in improving bioavailability.
Main Methods:
- Literature review focusing on drug solubility enhancement strategies.
- Analysis of the biopharmaceutical classification system's relevance to drug solubility.
- Evaluation of nanomedicine approaches, particularly lipid-based nanosystems.
Main Results:
- Nanonization significantly increases drug surface area, enhancing saturation solubility and dissolution rates.
- Lipid-based nanosystems are effective nanocarriers for poorly water-soluble drugs.
- Several nanonization approaches are currently available on the market.
Conclusions:
- Nanonization is a crucial technique for improving the bioavailability of poorly water-soluble drugs.
- Establishing clear quality criteria for nanonized drugs is essential for nanomedicine safety and efficacy.
- Nanoparticles and nanocarriers offer promising solutions for pharmaceutical formulation challenges.
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