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Synthetic approaches towards bedaquiline and its derivatives
Matthew B Calvert1, Daniel P Furkert2, Christopher B Cooper3
1School of Chemical Sciences, The University of Auckland, Symonds Street, Auckland 1010, New Zealand.
Abstract:
Bedaquiline is a diarylquinoline drug that demonstrates potent and selective inhibition of mycobacterial ATP synthase, and is clinically administered for the treatment of multi-drug resistant tuberculosis. Due to its excellent activity and novel mechanism of action, bedaquiline has been the focus of a number of synthetic studies. This review will discuss these synthetic approaches, as well as the synthesis and bioactivity of the numerous derivatives and molecular probes inspired by bedaquiline.
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