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A Reflection on 50 Years of John Maynard Smith's "Protein Space"

C Brandon Ogbunugafor1

  • 1Department of Ecology and Evolutionary Biology, Brown University, Providence, Rhode Island 02912 brandon_ogbunu@brown.edu.

Genetics
|April 16, 2020
PubMed

Keywords:
evolutionary geneticshistory of scienceprotein evolution

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Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
Protein Organization01:24

Protein Organization

Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence.