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The use of progesterone during pregnancy to prevent preterm birth

Eman S Alsulmi1, Malikah Alfaraj, Yaser Faden

  • 1From the Department of Obstetrics and Gynecology, King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Dammam, Kingdom of Saudi Arabia. E-mail. ealsulmi@gmail.com.

Saudi Medical Journal
|April 16, 2020
PubMed

Insights

Progesterone use in pregnancy is a key strategy for preventing preterm birth (PTB). This review provides clinical guidelines for progesterone

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Neonatology

Background:

  • Preterm birth (PTB) remains a significant global challenge in maternal and child health.
  • Despite advances, strategies to improve premature infant survival have not fully addressed PTB rates.
  • Progesterone gained FDA approval for PTB prevention nine years ago.

Purpose of the Study:

  • To review current evidence on progesterone's efficacy in preventing preterm birth.
  • To provide evidence-based guidelines for clinical use of progesterone in pregnancy.
  • To address controversial aspects of PTB prevention with progesterone.

Main Methods:

  • Literature review of recent evidence on progesterone for PTB prevention.
  • Development of clinical guidelines for progesterone use.
  • Analysis of controversial areas including multifetal gestation, formulations, safety, dose, and administration route.

Main Results:

  • Recent evidence supports the use of progesterone for PTB prevention.
  • Guidelines are provided to assist physicians in clinical decision-making.
  • Key areas of controversy are addressed to clarify clinical practice.

Conclusions:

  • Progesterone is a valuable tool in the prevention of preterm birth.
  • Standardized guidelines are essential for optimal clinical application.
  • Further clarification on controversial aspects will aid widespread adoption and efficacy.

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