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Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
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Nanoencapsulated dietary polyphenols for cancer prevention and treatment: successes and challenges

Shams Tabrez1,2, Nasimudeen R Jabir3, Vaqar Mustafa Adhami4

  • 1King Fahd Medical Research Center, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.

Nanomedicine (London, England)
|April 16, 2020
PubMed

Insights

Dietary polyphenols show anticancer promise, but poor delivery limits use. Nanoencapsulation enhances polyphenol delivery for cancer treatment, though further research is needed for clinical success.

Area of Science:

  • Biochemistry
  • Nanotechnology
  • Oncology

Background:

  • Dietary polyphenols exhibit significant anticancer properties in preclinical studies.
  • Clinical application of polyphenols is hindered by poor bioavailability, stability, and systemic delivery.

Purpose of the Study:

  • To review the application of nanoformulated polyphenols for cancer prevention and treatment.
  • To highlight the potential of nanoencapsulation to overcome delivery challenges.

Main Methods:

  • Review of existing literature on nanoencapsulated polyphenols.
  • Focus on specific polyphenols like epigallocatechin gallate, quercetin, curcumin, and resveratrol.
  • Analysis of nanoformulation strategies for cancer therapy.

Main Results:

  • Nanoencapsulation can improve polyphenol circulation time, tissue localization, and efficacy.
  • Nanoformulations may help overcome multidrug resistance in cancer cells.
  • Several polyphenols, including epigallocatechin gallate, quercetin, curcumin, and resveratrol, have shown promise in nanoformulations.

Conclusions:

  • Nanoencapsulation is a promising strategy to enhance the therapeutic potential of dietary polyphenols in cancer.
  • Further research is required to develop effective nanoencapsulated polyphenol combinations for clinical use.
  • Optimizing nanoformulations for *in vitro*, *in vivo*, and human systems is crucial for successful translation.
Keywords:
EGCGcancerchemopreventioncurcuminpolyphenolsquercetinresveratrol

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