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A dual-functional Embolization-Visualization System for Fluorescence image-guided Tumor Resection.

M Martin Jensen^1,2, Zachary B Barber^1,2, Nitish Khurana^2,3

¹Department of Bioengineering, University of Utah, Salt Lake City, UT, 84112 USA.

|April 16, 2020

Summary

This summary is machine-generated.

This study introduces a new dual-function system combining embolization and visualization for endoscopic tumor resection. The silk-elastinlike protein (SELP) and indocyanine green (ICG) system effectively controls bleeding and marks tumor margins during surgery.

Keywords:

Embolic Image-Guided Surgery Indocyanine Green Silk-Elastinlike Protein Polymer

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Area of Science:

Biomaterials Science
Surgical Oncology
Medical Imaging

Background:

Intraoperative bleeding complicates endoscopic tumor resection, especially for hypervascular head and neck tumors.
Improved visualization and bleeding control are crucial for enhancing surgical outcomes and reducing complications.

Purpose of the Study:

To develop and characterize a novel dual-function system for pre-surgical embolization and enhanced visualization during endoscopic tumor resection.
To combine silk-elastinlike protein (SELP) polymers with indocyanine green (ICG) for improved fluorescence-guided surgery.

Main Methods:

Silk-elastinlike protein (SELP) polymers were formulated as liquid embolic vehicles for indocyanine green (ICG) delivery.
Biophysical properties (gelation, elasticity, viscosity) of SELP-ICG were characterized using rheology.
ICG release kinetics were modeled, and embolic capability was tested in microfluidic tumor vasculature models.
Cytotoxicity of the SELP-ICG system was assessed in fibroblast and endothelial cell lines.

Main Results:

ICG incorporation into SELP accelerated gelation and increased elasticity, while maintaining injectability.
The SELP-ICG system demonstrated controlled ICG release (83% within 24 hours) and effective embolization in simulated vasculature.
Fluorescence imaging confirmed sufficient dye diffusion for tumor visualization, and the system showed biocompatibility with endothelial cells.

Conclusions:

A novel dual-functional embolization-visualization system using SELP-ICG was successfully developed and characterized.
This system holds potential for improving gross tumor resection, reducing blood loss, and enhancing outcomes in endoscopic surgery for hypervascular tumors.