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A living systematic review protocol for COVID-19 clinical trial registrations

Brittany J Maguire1,2, Philippe J Guérin1,2

  • 1Infectious Diseases Data Observatory (IDDO), Oxford, UK.

Wellcome Open Research
|April 16, 2020
PubMed

Insights

This living systematic review tracks COVID-19 clinical trial registrations, offering a continuously updated resource for researchers. It synthesizes trial data to guide future research and identify effective interventions for coronavirus disease 2019.

Area of Science:

  • Public Health
  • Infectious Diseases
  • Clinical Trials

Background:

  • The COVID-19 pandemic has spurred extensive research, including numerous clinical trials for diagnostics, therapeutics, and prophylactics.
  • Despite global efforts, no definitive treatments or preventive measures for COVID-19 have been established.
  • A comprehensive overview of ongoing clinical trials is crucial for navigating the research landscape and identifying high-priority studies.

Purpose of the Study:

  • To create a living, systematic review of COVID-19 clinical trial registrations.
  • To provide an open, accessible, and frequently updated resource summarizing trial characteristics.
  • To aid researchers in understanding the current research landscape and prioritizing future investigations.

Main Methods:

  • Conducting weekly searches of the WHO International Clinical Trials Registry Platform (ICTRP) and other registries.
  • Extracting data on trial design, location, interventions, evidence levels, and adaptability to low-resource settings by two independent reviewers.
  • Performing descriptive and thematic synthesis, and creating a searchable, interactive online visualization of the results.

Main Results:

  • A continuously updated database of COVID-19 clinical trial registrations will be made available.
  • Weekly publications of search results will be published on the Infectious Diseases Data Observatory (IDDO) website.
  • The review will categorize trials by intervention, evidence level, and suitability for low-resource settings.

Conclusions:

  • This living systematic review offers a valuable, dynamic resource for researchers in the rapidly evolving field of COVID-19 research.
  • The synthesized data will facilitate the prioritization of research targets for future meta-analyses.
  • The accessible online platform ensures broad dissemination of critical information on COVID-19 clinical trials.
Keywords:
COVID-19Living systematic reviewclinical trialscoronavirusemerging infections

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