Eye involvement in ANCA positive vasculitis

Area of Science:

• Immunology
• Rheumatology
• Ophthalmology

Background:

• Vasculitis encompasses diverse diseases characterized by blood vessel wall inflammation and necrosis.
• Key pathogenic mechanisms include immune complex deposition, anti-endothelial cell antibodies, and anti-lysosomal antibodies.
• Antineutrophil cytoplasmic antibodies (ANCA) are crucial in a subset of vasculitis, termed ANCA-associated vasculitis (AAV).

Purpose of the Study:

• To elucidate the multifaceted ocular manifestations in patients with ANCA-associated vasculitis.
• To provide a comprehensive overview of eye involvement in ANCA+ vasculitis.

Main Methods:

• Review of existing literature on ocular involvement in ANCA-associated vasculitis.
• Analysis of clinical data and case reports pertaining to eye complications in ANCA+ vasculitis.

Main Results:

• Detailed description of various ocular conditions associated with ANCA+ vasculitis.
• Highlighting the spectrum of eye damage, from anterior segment inflammation to posterior segment complications.

Conclusions:

• Ocular involvement is a significant concern in ANCA-associated vasculitis, impacting visual prognosis.
• Early recognition and management of eye manifestations are critical for preserving vision in patients with ANCA+ vasculitis.