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Updated: Dec 24, 2025

Microfluidics in Assessing Platelet Function
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Pro-inflammatory effects after platelet transfusion: a review.

Bin-Zhen Chen1, Rong Xia1

  • 1Department of Transfusion Medicine, Huashan Hospital, Fudan University, Shanghai, China.

Vox Sanguinis
|April 16, 2020
PubMed
Summary

Platelet transfusions can trigger inflammatory responses, involving platelet microparticles and other factors. Future research may focus on these mechanisms to improve transfusion safety and reduce adverse reactions.

Keywords:
plateletpro-inflammatorystrategiestransfusiontransfusion adverse reactions

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Area of Science:

  • Hematology
  • Immunology
  • Transfusion Medicine

Background:

  • Platelets are implicated in thrombosis and inflammation.
  • Platelet transfusions, a common therapy, carry risks like infection and lung injury.
  • Emerging evidence links platelet transfusions to pro-inflammatory effects.

Purpose of the Study:

  • To systematically review recent advances in understanding platelet transfusion-related inflammatory responses.
  • To identify key mechanisms contributing to adverse reactions from platelet transfusions.

Main Methods:

  • Systematic review of English literature from 2014 to 2019.
  • Abstraction of data on platelet transfusion-related reactions.
  • Application of inclusion and exclusion criteria for article selection.

Main Results:

  • Platelet transfusion is associated with pro-inflammatory processes.
  • Secretion of platelet microparticles and inflammatory factors are key components.
  • Focus on recent 5-year advances (2014-2019) highlights these findings.

Conclusions:

  • Platelet microparticles and biological response modifiers offer potential therapeutic targets.
  • Interventions targeting these pathways could reduce transfusion-related adverse reactions.
  • Improving pretransfusion manipulations may enhance the efficacy and safety of platelet transfusions.