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Updated: Dec 24, 2025
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Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
Published on: November 5, 2021
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Coronaviruses and SARS-COV-2
Mustafa Hasöksüz1, Selçuk Kiliç2, Fahriye Saraç3
1Department of Virology, Faculty of Veterinary Medicine, Istanbul University-Cerrahpaşa, İstanbul, Turkey
Turkish Journal of Medical Sciences
|April 16, 2020
Summary
Coronaviruses cause various animal and human diseases. The emergence of SARS-CoV-2 causing COVID-19 has led to a global pandemic with millions of cases and fatalities.
Area of Science:
- Virology
- Epidemiology
- Public Health
Background:
- Coronaviruses (CoVs) are a diverse group of viruses known to cause a range of illnesses in animals and humans, from common colds to severe respiratory diseases.
- Human coronavirus (HCoV) infections include common cold viruses (HCoV 229E, NL63, HKU1, OC43) and more severe pathogens like SARS-CoV and MERS-CoV.
Purpose of the Study:
- To provide an overview of coronaviruses, their impact on health, and the emergence of SARS-CoV-2.
- To document the initial spread and impact of COVID-19.
Main Methods:
- Literature review of coronavirus characteristics and known human infections.
- Analysis of epidemiological data for the initial COVID-19 outbreak.
Main Results:
- Coronaviruses cause significant enteric, respiratory, and systemic diseases in various hosts.
- The novel SARS-CoV-2 emerged in late 2019, causing the COVID-19 pandemic.
- By April 10, 2020, COVID-19 had resulted in over 1.7 million confirmed cases and 105,000 deaths globally.
Conclusions:
- Coronaviruses represent a significant threat to both animal and human health.
- The rapid global spread of SARS-CoV-2 highlights the need for effective public health surveillance and response strategies.
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