Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Renewal of Intestinal Stem Cells

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...

Development of Immunocompetence

Development of Immunocompetence

The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The discovery and roles of type 2 innate lymphoid cells.

Journal of immunology (Baltimore, Md. : 1950)·2026

Same author

Serotonin Degradation and Lipid Metabolism Regulate Human Tc2 Cell Effector Functions.

Allergy·2026

Same author

Intestinal resident effector-memory CD4 T cells on the adaptive-innate spectrum comprise IL-18 reactivity and adaptive CMV specificity.

Science advances·2026

Same author

Tumor-infiltrating immature innate lymphoid cells in colorectal cancer are biased toward ILC1/tissue-resident NK cell differentiation.

Nature communications·2026

Same author

MAIT cell responses to <i>S. aureus</i> and sensitivity to HlgAB are modulated by activation and tissue-dependent virulence effects.

bioRxiv : the preprint server for biology·2026

Same author

CXCR5 identifies stem-like resident memory CD8⁺ T cells enriched for latent EBV specificity in tonsils.

Science advances·2026

Search research articles

Related Experiment Video

Updated: Dec 24, 2025

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells

Published on: March 23, 2022

Tummy Time for ILC2.

Efthymia Kokkinou¹, Jenny Mjösberg¹

¹Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

|April 16, 2020

Summary

This summary is machine-generated.

Innate lymphoid cells type 2 (ILC2) play a key role in stomach immunity against Helicobacter pylori infection. This study reveals a novel immune pathway involving ILC2s that helps control this common bacterial pathogen.

More Related Videos

Assessment of the Efficacy of An Osteopathic Treatment in Infants with Biomechanical Impairments to Suckling

Assessment of the Efficacy of An Osteopathic Treatment in Infants with Biomechanical Impairments to Suckling

Published on: February 5, 2019

Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine

Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine

Published on: June 24, 2019

Related Experiment Videos

Last Updated: Dec 24, 2025

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells

Published on: March 23, 2022

Assessment of the Efficacy of An Osteopathic Treatment in Infants with Biomechanical Impairments to Suckling

Assessment of the Efficacy of An Osteopathic Treatment in Infants with Biomechanical Impairments to Suckling

Published on: February 5, 2019

Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine

Intravital Imaging of Intraepithelial Lymphocytes in Murine Small Intestine

Published on: June 24, 2019

Area of Science:

Immunology
Microbiology
Gastroenterology

Background:

Host-microbiota interactions in the stomach are not well understood.
Helicobacter pylori infection is linked to gastric inflammation and cancer.

Purpose of the Study:

To investigate the role of innate lymphoid cells type 2 (ILC2) in anti-microbial immunity in the stomach.
To elucidate the immune mechanisms controlling Helicobacter pylori infection.

Main Methods:

The study involved analyzing immune responses in the gastric environment.
Specific focus was placed on the function of ILC2s during H. pylori infection.

Main Results:

Satoh-Takayama et al. identified a previously unknown immune mechanism involving ILC2s.
These ILC2s were found to be crucial in controlling Helicobacter pylori infection.

Conclusions:

Innate lymphoid cells type 2 (ILC2) represent an important component of gastric anti-microbial immunity.
ILC2s offer a new therapeutic target for managing H. pylori-associated diseases.