Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Erythroferrone Modulates Osteoblast-Osteoclast Crosstalk During Bone Remodeling.

bioRxiv : the preprint server for biology·2026
Same author

Network clustering algorithms and preprocessing pipelines for robust cell type identification in single-cell RNA sequencing data.

Scientific reports·2026
Same author

Trait-Relevant Tasks Improve Personality Prediction From Structural-Functional Brain Network Coupling.

Human brain mapping·2026
Same author

Erythroferrone derived from osteoblasts regulates stress erythropoiesis.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Cortical similarity networks in the rat brain: Postnatal development and sensitivity to early life stress.

Network neuroscience (Cambridge, Mass.)·2026
Same author

Structural signatures of synergy and redundancy in human brain function.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Dec 24, 2025

Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging
06:18

Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging

Published on: November 21, 2023

1.2K

Network Analysis of Murine Cortical Dynamics Implicates Untuned Neurons in Visual Stimulus Coding.

Maayan Levy1, Olaf Sporns2, Jason N MacLean3

  • 1Committee on Computational Neuroscience, The University of Chicago, Chicago, IL 60637, USA.

Cell Reports
|April 16, 2020
PubMed
Summary

Untuned neurons in the mouse visual cortex (V1) play a central role in functional networks, contributing significantly to visual stimulus representation. Manipulating either tuned or untuned neurons equally impacts decoding accuracy, highlighting their integral network function.

Keywords:
functional networkneural codeuntuned neurons

More Related Videos

Targeted Labeling of Neurons in a Specific Functional Micro-domain of the Neocortex by Combining Intrinsic Signal and Two-photon Imaging
11:24

Targeted Labeling of Neurons in a Specific Functional Micro-domain of the Neocortex by Combining Intrinsic Signal and Two-photon Imaging

Published on: December 12, 2012

14.0K
Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents
07:52

Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents

Published on: May 23, 2025

701

Related Experiment Videos

Last Updated: Dec 24, 2025

Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging
06:18

Author Spotlight: Deciphering Neural Circuit Formation from Two-Photon Microscopy and Single Neuron Imaging

Published on: November 21, 2023

1.2K
Targeted Labeling of Neurons in a Specific Functional Micro-domain of the Neocortex by Combining Intrinsic Signal and Two-photon Imaging
11:24

Targeted Labeling of Neurons in a Specific Functional Micro-domain of the Neocortex by Combining Intrinsic Signal and Two-photon Imaging

Published on: December 12, 2012

14.0K
Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents
07:52

Multiscale Investigations of Cortical Processing by Integrating Laminar Polytrodes and Optogenetics with Micro Electrocorticography in Rodents

Published on: May 23, 2025

701

Area of Science:

  • Neuroscience
  • Computational Neuroscience

Background:

  • Layer 2/3 pyramidal neurons in mouse primary visual cortex (V1) form functional sub-populations: tuned and untuned to drifting gratings.
  • The role of functional interactions between these neuronal groups in visual stimulus representation remains unclear.

Purpose of the Study:

  • To investigate the functional interactions between tuned and untuned neurons in V1.
  • To determine the contribution of these interactions to visual stimulus representation.

Main Methods:

  • Dense sampling of layer 2/3 pyramidal neurons in mouse V1.
  • Analysis of population partial pairwise correlation structure as a directed and weighted graph.
  • Implementation of a decoder utilizing functional network topology.

Main Results:

  • Untuned neurons exhibit distinct topological properties, occupying central positions in functional networks (FNs).
  • A decoder based on FN topology accurately decodes visual stimuli.
  • Decoding performance degrades comparably after manipulating either tuned or untuned neurons.

Conclusions:

  • Untuned neurons are integral components of V1 functional networks.
  • Network interactions, including those involving untuned neurons, contain stimulus-relevant information accessible to downstream elements.