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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Genetics

Background:

  • Kinases like PI3K, mTOR, and ERK are well-researched for disease links.
  • The NEK (Never in mitosis, abridged kinase) family remains understudied despite its importance.
  • NEKs are homologous kinases involved in cell cycle, cell division, cilia formation, and DNA damage response.

Purpose of the Study:

  • To review the NEK family's role in human diseases.
  • To elucidate the regulatory mechanisms of NEKs in disease pathogenesis.
  • To identify knowledge gaps and future research directions for NEKs.

Main Methods:

  • Comprehensive literature review of NEK family kinases.
  • Analysis of NEK involvement in various cellular processes.
  • Correlation of NEK functions with human disease development.

Main Results:

  • NEKs play a pivotal role in diverse human diseases, including cancers, diabetes, ciliopathies, and neurological/inflammatory disorders.
  • Specific regulatory mechanisms for individual NEKs in disease contexts are identified.
  • Significant gaps in understanding NEK biology and disease associations remain.

Conclusions:

  • The NEK family is integral to cellular functions and implicated in major human diseases.
  • Targeting NEKs presents a promising therapeutic avenue for various conditions.
  • Further research is essential to fully unlock the therapeutic potential of the NEK family.