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Potential CNS active agents. II--Studies of 4(3H)-quinazolinones
Il Farmaco; Edizione Scientifica
|September 1, 1988
Abstract:
Some new 2-carbamoylmethylthio- and 2-(omega-dimethylamino-alkyl)thio-3-aryl-7-chloro-4(3H)-quinazolinones have been prepared from 2-thio-3-aryl-7-chloro-4(3H)-quinazolinones as the key intermediate. Five of the synthetic compounds were screened for their CNS activities on mice and found to be either CNS depressants or stimulants.