[The mechanisms of memory disorders at the stages in its acquisition and fixation]

The blockade of cholinergic system with scopolamine (10 mg/kg) did not impair the process of memory acquisition in rats but disrupted the process of memory fixation or consolidation, the disturbance stemming from the ketamine-blocked ion-channels of nicotinic receptors. Both scopolamine and ketamine impaired the process of memory recall, being more efficient in the case of ketamine. Piracetam (40 mg/kg) diminished the impair of fixation induced with scopolamine but did not affect the ketamine-induced impairment of memory acquisition.