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Microbiome in Multiple Sclerosis; Where Are We, What We Know and Do Not Know

Marina Kleopatra Boziki1, Evangelia Kesidou1, Paschalis Theotokis1

  • 12nd Neurological University Department, Aristotle University of Thessaloniki, AHEPA General Hospital, 54634 Thessaloniki, Greece.

Brain Sciences
|April 17, 2020
PubMed

Insights

Multiple sclerosis (MS) incidence is rising, potentially linked to environmental factors. This review explores the gut-brain axis and how disease-modifying treatments impact the gut microbiome in MS patients.

Area of Science:

  • Neuroimmunology
  • Microbiome Research
  • Environmental Health

Background:

  • Rising incidence of multiple sclerosis (MS) suggests environmental influences.
  • The gut-brain axis is a critical communication pathway between the central nervous system and gut microbiota.
  • Understanding these connections is vital for MS pathogenesis and treatment.

Purpose of the Study:

  • To review current research on the gut-brain axis in relation to multiple sclerosis.
  • To summarize findings on the impact of disease-modifying treatments on the gut microbiome of MS patients.

Main Methods:

  • Literature review of recent studies on MS, gut-brain axis, and gut microbiome.
  • Analysis of clinical data assessing treatment effects on MS patient gut microbiota.

Main Results:

  • The gut-brain axis plays a significant role in mediating MS.
  • Disease-modifying treatments can alter the gut microbiome composition in MS patients.

Conclusions:

  • Environmental factors and the gut microbiome are increasingly recognized as important in MS.
  • Further research into the gut-brain axis and microbiome modulation holds therapeutic potential for MS.
Keywords:
disease-modifying treatmentsgut microbiomegut–brain axismetagenomicsmultiple sclerosis

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