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Effect of oxodipine and nifedipine on guinea-pig ileum
M Martin1, M J Alfaro, J Tamargo
1Department of Pharmacology, School of Medicine, Universidad Complutense, Madrid, Spain.
General Pharmacology
|January 1, 1988
Abstract:
1. The effects of oxodipine, a new dihydropyridine, were studied and compared with those of nifedipine in guinea-pig ileum. 2. Oxodipine and nifedipine, 10(-8)-10(-7) M, produced a dose-dependent inhibition of the contractile responses induced by single pulse stimulation, acetylcholine and histamine. 3. From these experiments it is concluded that oxodipine like nifedipine produced a similar and potent inhibitory effect of the contractile responses induced in guinea-pig ileum.