Related Experiment Video
Updated: Dec 24, 2025

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
Published on: December 5, 2016
Epigenetic N6-methyladenosine modification of RNA and DNA regulates cancer
Zhixian Liang1,2, Reilly L Kidwell3,4, Haijing Deng1,2
1School of Life Sciences, Westlake University, Hangzhou 310024, China.
Abstract:
The biological roles of N6 methylation of nucleic acids have been extensively studied. Adenine methylation of RNA is the most prevalent RNA modification and has widespread effects on RNA splicing, translation, localization, and stability. Aberrant dynamic regulation of RNA N6-methyladenosine (m6A) has been reported in numerous human diseases, including several cancers. In recent years, eukaryotic DNA N6-methyladenosine (6mA) has also been reported and implicated in cancer progression and tumorigenesis. In this review, we summarize the contributions of N6-methyladenosine modification to cancer biology and pathogenesis in the context of both RNA and DNA. We also highlight the clinical relevance of targeting these modifications as a therapeutic strategy for cancer.
Related Concept Videos
Epigenetic Regulation
X-chromosome...
Epigenetic Regulation
RNA Stability
RNA Editing
Chromatin Structure Regulates pre-mRNA Processing
The chromatin structure, especially...
MicroRNAs

