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Updated: Dec 24, 2025
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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
Published on: March 20, 2020
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Metabolic reprogramming in triple-negative breast cancer
Zhanyu Wang1, Qianjin Jiang2, Chenfang Dong1,2
1Department of Surgical Oncology (Breast Center) of The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China.
Cancer Biology & Medicine
|April 17, 2020
Summary
Triple-negative breast cancer (TNBC) hijacks cellular metabolism for aggressive growth and metastasis. Understanding these metabolic changes offers new therapeutic targets for TNBC intervention.
Area of Science:
- Oncology
- Metabolic pathways
- Cancer biology
Background:
- Triple-negative breast cancer (TNBC) presents significant clinical challenges due to its aggressiveness and limited targeted therapies.
- Patients with TNBC generally experience poorer outcomes compared to other breast cancer subtypes.
- Metabolic reprogramming is a critical hallmark of cancer, enabling tumor growth and progression.
Purpose of the Study:
- To review the metabolic reprogramming landscape in triple-negative breast cancer.
- To explore the role of altered metabolic pathways in TNBC aggressiveness and metastasis.
- To identify potential opportunities for novel biomarkers and targeted therapies for TNBC.
Main Methods:
- Comprehensive literature review of metabolic reprogramming in TNBC.
- Analysis of key metabolic pathways including glycolysis, oxidative phosphorylation, amino acid, and lipid metabolism.
- Exploration of emerging therapeutic strategies targeting cancer metabolism.
Main Results:
- TNBC extensively reprograms core metabolic pathways to meet its high bioenergetic and biosynthetic demands.
- Altered metabolism supports redox balance, oncogenic signaling, proliferation, and metastasis in TNBC.
- Specific metabolic vulnerabilities in TNBC offer potential targets for intervention.
Conclusions:
- Metabolic reprogramming is a fundamental driver of TNBC progression and aggressiveness.
- Targeting metabolic pathways presents a promising avenue for developing novel TNBC treatments.
- Further research into TNBC metabolism may yield new biomarkers and imaging modalities.
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