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Core-Shell Spheroidal Hydrogels Produced via Charge-Driven Interfacial Complexation.

Vincenzo Calabrese1, Davide Califano1,2, Marcelo A da Silva1

  • 1Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom.

ACS Applied Polymer Materials
|April 17, 2020
PubMed
Summary
This summary is machine-generated.

We developed stable, millimeter-sized spheroidal hydrogels (SH) with a core-shell structure. These hydrogels can encapsulate enzymes like glucose oxidase (GOx) for potential applications in reusable microreactors.

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Area of Science:

  • Materials Science
  • Polymer Chemistry
  • Biomaterials Engineering

Background:

  • Hydrogels are versatile materials with applications in various fields.
  • Developing hydrogels with controlled structures and long-term stability in aqueous environments remains a challenge.
  • Core-shell hydrogels offer unique properties for encapsulation and controlled release.

Purpose of the Study:

  • To produce millimeter-sized spheroidal hydrogels (SH) with a stable core-shell structure.
  • To investigate the swelling behavior of SH in response to varying osmotic pressures and ionic strengths.
  • To demonstrate the potential of SH as reusable matrices for enzyme immobilization.

Main Methods:

  • Fabrication of SH via interfacial complexation of cationic cellulose nanofibril (CCNF) dispersion and poly(acrylic acid) (PAA) bath.
  • Characterization of SH structure and stability in aqueous media.
  • Assessment of SH swelling behavior under different osmotic pressures and ionic strengths.
  • Evaluation of SH as a matrix for glucose oxidase (GOx) entrapment and its performance as a microreactor.

Main Results:

  • Successfully produced millimeter-sized SH with a stable core-shell structure.
  • SH exhibited semipermeable membrane-like properties due to the CCNF-PAA shell.
  • Swelling behavior was tunable by adjusting the osmotic pressure and ionic strength of the surrounding media.
  • SH demonstrated effective entrapment of glucose oxidase, preventing leakage while allowing substrate and product diffusion.

Conclusions:

  • Charge-driven interfacial complexation is an effective method for creating stable core-shell spheroidal hydrogels.
  • The developed SH show promise as tunable microreactors for enzyme immobilization and reuse.
  • The ability to control swelling through ionic strength offers a pathway for optimizing hydrogel performance in specific applications.