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Updated: Dec 24, 2025
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[Bilateral effusion syndrome induced by chlorthalidon]
Gelareh Winter1, Ulrich Schaudig2, Birthe Stemplewitz2
1Klinik für Augenheilkunde, Asklepios Klinik Barmbek, Rübenkamp 220, 22307, Hamburg, Deutschland. ge.winter@asklepios.com.
Summary
Chlorthalidone, a diuretic, can cause uveal effusion leading to angle-closure glaucoma. Discontinuation of this medication resolved the effusion and glaucoma symptoms in a patient.
Area of Science:
- Ophthalmology
- Pharmacology
Background:
- Uveal effusion is a condition characterized by fluid accumulation in the choroid.
- This can lead to secondary angle-closure glaucoma, causing significant visual impairment.
Observation:
- A 57-year-old male presented with headache, vertigo, and reduced visual acuity.
- Ocular examination revealed a myopic shift and angle-closure glaucoma attributed to uveal effusion.
Findings:
- The patient had recently started chlorthalidone as part of his antihypertensive regimen.
- Discontinuation of chlorthalidone resulted in the complete resolution of uveal effusion and associated glaucoma.
Implications:
- Chlorthalidone can induce uveal effusion and secondary angle-closure glaucoma.
- Prompt recognition and discontinuation of the offending agent are crucial for managing this condition.
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