Poly (butylene succinate) and derivative copolymer filled with Dendranthema grandiflora biolarvicide extract

Dengue is the most important infectious disease in the world and is a severe public health problem. The chikungunya is an arbovirus, in many cases, increased, which is transmitted by the same transmitter dengue vector, Aedes aegypti. The symptoms of both diseases are similar, and infections can be lethal. Although there is no preventive vaccine against any of the two diseases, therefore, it is extremely important to control the mosquito. The eggs of A. aegypti are very resistant and hatch into larvae, which later give rise to mosquitoes in any container with water. Natural plant extracts have come from active substances with larvicidal activity against A. aegypti. However, they tend to be highly hydrophobic and need some strategy to improve its affinity for water. Because of these factors, this research aims to synthesize and characterize polymeric materials with properties suitable for the release of hydrophobic principles with larvicidal action. The synthesized polymers are poly (butylene succinate) (PBS) and PBS block copolymer with polyethylene glycol (PEG). The synthesized polymers were characterized by nuclear magnetic resonance, thermal analysis simultaneous, differential scanning calorimetry, Fourier transform infrared spectroscopy, and diffraction of X-rays analysis. The analysis results showed that the synthesized materials have chemical composition and properties suitable for use in the controlled release of actives substances. Systems were prepared using the Dendranthema grandiflora extract, which has larvicidal activity was incorporated via fusion to polymers, to evaluate its release in aqueous media. The results proved that higher amounts of PEG in the copolymer chain speed up the delivery of the larvicidal extract. Besides that, the larvicidal extract concentration required to cause death larvae of A. aegypti was achieved from the first minutes of dissolution tests, indicating that the materials developed are promising tool to fight dengue and chikungunya. This new system is a vital tool for eliminating vectors, potentially contributing to saving millions of lives worldwide.