Related Experiment Video

Updated: Dec 24, 2025

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models
04:25

Intratibial Osteosarcoma Cell Injection to Generate Orthotopic Osteosarcoma and Lung Metastasis Mouse Models

Published on: October 28, 2021

11.0K

Morusin Inhibits Human Osteosarcoma via the PI3K-AKT Signaling Pathway

Yong Zhang1, Qiuyan Weng2, Jianming Chen1

  • 1Departments of Trauma Orthopedics, Ningbo No. 6 Hospital, Ningbo 315000, Zhejiang, China.

Current Pharmaceutical Biotechnology
|April 17, 2020
PubMed
Abstract

Insights

Morusin effectively inhibits osteosarcoma cell growth and triggers cell death. This natural compound shows promise as a novel therapeutic agent for osteosarcoma, targeting the PI3K/AKT pathway.

Area of Science:

  • Oncology
  • Pharmacology
  • Biochemistry

Background:

  • Osteosarcoma is a prevalent bone tumor in children and adolescents.
  • Existing therapies for osteosarcoma have limited efficacy, necessitating novel treatment strategies.
  • Morusin, a compound from Morus australis, exhibits anti-tumor properties in various cancers, but its effect on osteosarcoma is unexplored.

Purpose of the Study:

  • To investigate the anti-cancer effects of morusin on osteosarcoma cells.
  • To elucidate the underlying molecular mechanisms of morusin's action in osteosarcoma.

Main Methods:

  • Osteosarcoma cell lines were treated with varying concentrations of morusin.
  • Cell proliferation, apoptosis, migration, and invasion assays were performed.
  • The involvement of the PI3K/AKT signaling pathway was assessed.

Main Results:

  • Morusin significantly inhibited osteosarcoma cell proliferation.
  • Morusin treatment promoted apoptosis in osteosarcoma cells.
  • Morusin reduced osteosarcoma cell migration and invasion by inhibiting the PI3K/AKT pathway.

Conclusions:

  • Morusin demonstrates potent anti-osteosarcoma activity.
  • Morusin effectively suppresses tumor cell growth, induces apoptosis, and reduces metastasis.
  • Morusin represents a potential therapeutic candidate for osteosarcoma treatment.
Keywords:
MMPsMorusinPI3K/AKThuman osteosarcomaosteosarcomatherapy

More Related Videos

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment11:13

Author Spotlight: Exploring Salidroside's Molecular Mechanisms in Breast Cancer Treatment

Published on: June 9, 2023

2.1K
Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

7.6K

Related Concept Videos

PI3K/mTOR/AKT Signaling Pathway01:22

PI3K/mTOR/AKT Signaling Pathway

The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
5.1K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
4.5K
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
11.5K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.0K