Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

4.5K
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.5K
Stem Cell Culture01:17

Stem Cell Culture

5.9K
Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.9K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.7K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unveiling the potential of solid lipid nanoparticles of apigenin-Cu(II) coordinated nanocomplex in colon cancer.

Naunyn-Schmiedeberg's archives of pharmacology·2026
Same author

Unveiling the Potential of Drug Delivery Systems for Tyrosine Kinase Inhibitors in the Treatment of Neovascular Eye Diseases.

Critical reviews in therapeutic drug carrier systems·2026
Same author

Structurally Modified Cyclodextrins in Topical Nanotechnology: Advancing Barrier-Penetrating Drug Delivery Strategies for Psoriasis Management.

AAPS PharmSciTech·2026
Same author

Blend of polymeric nanoparticles-in-microneedle arrays: A potential transepidermal route for genistein for anti-melanoma activity.

International journal of pharmaceutics·2025
Same author

Gold nanoparticle embedded color changing film for theranostics application in wound management.

Naunyn-Schmiedeberg's archives of pharmacology·2025
Same author

Bimetallic nanoprobe strip for the detection of human chorionic gonadotrophin in pregnancy.

Medical engineering & physics·2025

Related Experiment Video

Updated: Dec 24, 2025

A Culture Method to Maintain Quiescent Human Hematopoietic Stem Cells
07:14

A Culture Method to Maintain Quiescent Human Hematopoietic Stem Cells

Published on: May 17, 2021

5.2K

Current Trend and Pro-survival Approaches for Augmenting Stem Cell Viability.

Pravin Shende1, Nivedita Gandhewar1

  • 1Shobhaben Pratapbhai Patel School Pharmacy and Technology Management SVKM'S NMIMS, V.L Mehta Road, Vile Parle(W), Mumbai, India.

Current Pharmaceutical Biotechnology
|April 17, 2020
PubMed
Summary

Enhancing stem cell viability is crucial for regenerative medicine. Strategies like hydrogel scaffolds and pathway activation protect stem cells from damage and improve therapeutic outcomes.

Keywords:
HIF1PI3K/AKTViabilitymesenchymal stem cellpreconditioningpro-survival strategies

More Related Videos

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness
08:53

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Published on: August 31, 2016

15.8K
Culturing Human Pluripotent and Neural Stem Cells in an Enclosed Cell Culture System for Basic and Preclinical Research
08:05

Culturing Human Pluripotent and Neural Stem Cells in an Enclosed Cell Culture System for Basic and Preclinical Research

Published on: June 10, 2016

10.8K

Related Experiment Videos

Last Updated: Dec 24, 2025

A Culture Method to Maintain Quiescent Human Hematopoietic Stem Cells
07:14

A Culture Method to Maintain Quiescent Human Hematopoietic Stem Cells

Published on: May 17, 2021

5.2K
Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness
08:53

Competitive Transplants to Evaluate Hematopoietic Stem Cell Fitness

Published on: August 31, 2016

15.8K
Culturing Human Pluripotent and Neural Stem Cells in an Enclosed Cell Culture System for Basic and Preclinical Research
08:05

Culturing Human Pluripotent and Neural Stem Cells in an Enclosed Cell Culture System for Basic and Preclinical Research

Published on: June 10, 2016

10.8K

Area of Science:

  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Stem cells, including embryonic and adult types, are vital for tissue repair and differentiation.
  • They hold therapeutic potential for conditions like Parkinson's disease, diabetes, and spinal cord injury.

Purpose of the Study:

  • This article reviews advancements in stem cell viability research.
  • It addresses challenges that reduce the efficacy of transplanted stem cells.

Main Methods:

  • Investigating techniques to improve stem cell survival post-transplantation.
  • Exploring methods like hydrogel/alginate scaffolds, pre-conditioning, and encapsulation.

Main Results:

  • Various methods are employed to enhance stem cell viability.
  • These include scaffold-based delivery, pre-conditioning, and encapsulation techniques.

Conclusions:

  • Key signaling pathways like PI3K/AKT, HIF1, MAPK, and Hippo protect stem cells from apoptosis.
  • Activating PI3K/AKT reduces apoptotic factors, while HIF1 combats hypoxic environments.