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Updated: Dec 24, 2025
Methionine Functionalized Biocompatible Block Copolymers for Targeted Plasmid DNA Delivery
Published on: August 6, 2019
Aza-crown ether locked on polyethyleneimine: solving the contradiction between transfection efficiency and safety
Shengran Li1, Lin Lin, Wenliang Wang
1Laboratory of Polymer Composites Engineering, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China. liusanrong@ciac.ac.cn xjma@ciac.ac.cn xfyu@ciac.ac.cn.
Abstract:
We proposed a method using an aza-crown ether derivative to lock a hyperbranched polyethyleneimine, which endows the PEI25k with tumor targeting ability, anti-serum ability and extended circulation in the blood meanwhile retaining the high gene complexation and high transfection efficiency. The method we proposed here simultaneously endows cationic materials with high transfection efficiency and high safety, which greatly pushed the cationic materials to be applied in in vivo gene delivery.
