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Toxicity of astatine-211 in the mouse

L M Cobb1, A Harrison, S A Butler

  • 1Division of Experimental Pathology and Therapeutics, MRC Radiobiology Unit, Didcot, Oxon, UK.

Human Toxicology
|November 1, 1988
PubMed

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...
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