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Updated: Dec 24, 2025

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Published on: September 5, 2014
Aerodynamic Thermal Breakup Droplet Ionization in Mass Spectrometric Drug Analysis
Viktor V Pervukhin1, Dmitriy G Sheven1
1Nikolaev Institute of Inorganic Chemistry of SB RAS, 3, Academy Lavrentieva Avenue, 630090 Novosibirsk, Russia.
Abstract:
Aerodynamic thermal breakup droplet ionization (ATBDI) in mass spectrometric drug analysis is considered. Cocaine, heroin, and the main alkaloids of opium (morphine, codeine, papaverine) were chosen as the test compounds. The principles of ATBDI ionization are discussed. The dependences of the intensities of the peaks of the target compounds on temperature during ATBDI ionization are also considered. In some cases, a comparison of ATBDI ionization with electrospray ionization (ESI) was performed. In addition, a comparison of methods is demonstrated by the analysis of confiscated opium that was provided by the local police department. Five major alkaloids are found in opium: morphine, codeine, thebaine, papaverine, and narcotine.
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