The coxsackievirus and adenovirus receptor: virological and biological beauty

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Updated: Dec 24, 2025

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16
06:03

Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16

Published on: July 15, 2019

8.3K

Katherine J D A Excoffon1,2

  • 1Biological Sciences, Wright State University, Dayton, OH, USA.

FEBS Letters
|April 17, 2020
PubMed

Insights

The coxsackievirus and adenovirus receptor (CAR) is a key protein involved in viral entry and cell functions. Understanding CAR

Area of Science:

  • Cell Biology
  • Virology
  • Molecular Biology

Background:

  • The coxsackievirus and adenovirus receptor (CAR) is a crucial multifunctional protein.
  • CAR acts as a receptor for adenoviruses, coxsackieviruses, and other viruses.
  • CAR also plays roles in cell adhesion, immune activation, and signaling.

Purpose of the Study:

  • To explore the multifaceted biological functions of CAR.
  • To investigate the complexity of CAR isoforms and their activities.
  • To identify CAR-interacting proteins and their roles.

Main Methods:

  • Utilizing knockout mouse models to identify initial CAR functions.
  • Employing tissue-specific model systems to study CAR isoforms.
  • Analyzing protein-protein interactions to discover new CAR partners.

Main Results:

  • CAR's involvement in viral receptor functions is established.
  • Diverse biological roles beyond viral entry have been elucidated.
  • Multiple CAR isoforms exhibit distinct activities.
  • Numerous CAR-interacting proteins have been identified, with new ones discovered.

Conclusions:

  • CAR is a critical protein with diverse cellular functions.
  • Understanding CAR isoforms and interactions is essential for future research.
  • Further investigation into manipulating CAR in vivo is critical for therapeutic strategies.
Keywords:
CARPDZ domainadenoviruscoxsackievirusgene therapyprotein isoformsrhesus enteric calicivirusswine vesicular disease virus

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