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Lactobacillus HY2782 and Bifidobacterium HY8002 Decrease Airway Hyperresponsiveness Induced by Chronic PM2.5

Woo Nam1, Hyeonji Kim1, Chuhyun Bae1

  • 1R&D Center, Korea Yakult Co. Ltd., Yongin, Korea.

Journal of Medicinal Food
|April 17, 2020
PubMed
Summary

Two probiotics, Lactobacillus casei HY2782 and Bifidobacterium lactis HY8002, were found to protect against lung inflammation caused by fine particulate matter (PM2.5) exposure in mice. These probiotics reduced oxidative stress and inflammatory responses, offering a potential therapeutic strategy.

Keywords:
Bifidobacterium lactis HY8002Lactobacillus casei HY2782particulate matterprobioticspulmonary disease

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Area of Science:

  • Environmental Health
  • Microbiology
  • Immunology

Background:

  • Particulate matter (PM) exposure is linked to adverse health outcomes, particularly pulmonary diseases from fine particulate matter (PM2.5).
  • The precise molecular mechanisms driving lung inflammation after PM inhalation remain incompletely understood.

Purpose of the Study:

  • To investigate the protective effects of Lactobacillus casei HY2782 and Bifidobacterium lactis HY8002 against PM2.5-induced pulmonary inflammation.
  • To elucidate the impact of these probiotics on oxidative stress and inflammatory markers in a mouse model.

Main Methods:

  • Mice were chronically exposed to PM2.5 and orally administered with either HY2782 or HY8002 probiotics.
  • Assessed leukocyte migration, pro-inflammatory cytokine activation, and immune cell infiltration (eosinophils, neutrophils) in bronchoalveolar lavage fluid.
  • Measured reactive oxygen species (ROS) scavenging and antioxidant enzyme activities (superoxide dismutase, catalase) in blood.

Main Results:

  • PM2.5 exposure increased oxidative stress and Th2 cytokine responses in mice.
  • Oral administration of HY2782 and HY8002 ameliorated PM2.5-induced leukocyte migration and pro-inflammatory cytokine activation.
  • Both probiotics prevented increased eosinophil and neutrophil infiltration and enhanced ROS scavenging and antioxidant enzyme activity.

Conclusions:

  • Lactobacillus casei HY2782 and Bifidobacterium lactis HY8002 demonstrate significant protective effects against PM2.5-induced pulmonary inflammation.
  • These probiotics mitigate oxidative stress and modulate immune responses, suggesting their potential as a therapeutic intervention for air pollution-related lung conditions.