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Updated: Dec 24, 2025

Generating Genetically Modified Plasmodium berghei Sporozoites
Published on: May 5, 2023
Transition from Plasmodial Hypnozoite to Schizont Demonstrated
1School of Animal, Plant and Environmental Sciences, Faculty of Science, University of Witwatersrand, Johannesburg, South Africa; Wits Research Institute for Malaria, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
Abstract:
The progression to schizont formation of individual activated hypnozoites has been observed in vitro for the first time by Voorberg-van der Wel et al. Green-fluorescent protein-positive hypnozoites turned red-fluorescent (mCherry) upon activation. Thus, we now have empirical parasitological proof that supports the 40-year-old hypnozoite theory of relapse in malaria.
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