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Intussusceptive angiogenesis as a key therapeutic target for cancer therapy

Sekaran Saravanan1, Selvaraj Vimalraj2, Koka Pavani2

  • 1Centre for Nanotechnology & Advanced Biomaterials (CeNTAB), Department of Bioengineering, School of Chemical and Biotechnology, SASTRA University, Thanjavur 613 401, Tamil Nadu, India.

Life Sciences
|April 17, 2020
PubMed

Insights

Tumor growth resistance to anti-angiogenic drugs is linked to compensatory angiogenesis. Intussusceptive angiogenesis (IA) is a key mechanism driving this resistance, making it a promising target for novel cancer therapies.

Area of Science:

  • Oncology
  • Vascular Biology
  • Molecular Biology

Background:

  • Tumor growth and progression are driven by deregulated angiogenesis.
  • Current anti-angiogenic therapies face challenges due to acquired drug resistance.
  • Compensatory angiogenesis mechanisms contribute to treatment failure.

Purpose of the Study:

  • To elucidate the role of intussusceptive angiogenesis (IA) in tumors resistant to anti-VEGF therapies.
  • To identify key genes and signaling pathways regulating IA.
  • To explore IA as a potential therapeutic target for cancer treatment.

Main Methods:

  • Review of existing literature on tumor angiogenesis.
  • Development and utilization of a novel ex-ovo chick embryo model for IA studies.
  • Bio-informatic analysis of genes involved in sprouting angiogenesis (SA) and IA.
  • Examination of molecular interplay between SA, IA, and tumor progression factors.

Main Results:

  • Intussusceptive angiogenesis (IA) is identified as a critical compensatory mechanism in anti-VEGF resistant tumors.
  • Key genes and signaling pathways driving IA were elucidated.
  • The 'angiogenic switch' regulating the transition from SA to IA was analyzed.
  • Interactions between molecules regulating SA, IA, and tumor progression were investigated.

Conclusions:

  • Intussusceptive angiogenesis (IA) plays a vital role in tumor resistance to anti-VEGF therapies.
  • Understanding the molecular basis of IA provides insights into overcoming treatment resistance.
  • IA represents a promising therapeutic target for developing more effective anti-cancer strategies.
Keywords:
Angiogenic switchBiomarkersIntussusceptive angiogenesisSproutingTumor

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