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Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

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In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
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Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...
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The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
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Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
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Related Experiment Video

Updated: Dec 24, 2025

Inducing Acute Liver Injury in Rats via Carbon Tetrachloride CCl4 Exposure Through an Orogastric Tube
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COVID-19: Abnormal liver function tests.

Qingxian Cai1, Deliang Huang1, Hong Yu1

  • 1National Clinical Research Center for Infectious Diseases, The Third People's Hospital of Shenzhen, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong, 518100, China.

Journal of Hepatology
|April 17, 2020
PubMed
Summary
This summary is machine-generated.

COVID-19 significantly impacts liver function, with most patients showing abnormal liver tests. Abnormal liver tests indicate a higher risk of severe disease and potential medication-related liver injury requiring monitoring.

Keywords:
2019-nCoVBilirubinCritical careLiver injuryLiver testsPneumoniaSARS-Cov-2

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Area of Science:

  • Hepatology
  • Infectious Diseases
  • Internal Medicine

Background:

  • Limited data exists on liver test abnormalities in COVID-19 patients.
  • The study investigates the prevalence and impact of liver test abnormalities in COVID-19.
  • Liver injury and abnormal tests increased during hospitalization.

Purpose of the Study:

  • To systematically describe liver test abnormalities in COVID-19 patients.
  • To evaluate the clinical characteristics of COVID-19 patients with abnormal liver tests.
  • To assess the association between liver abnormalities and disease severity.

Main Methods:

  • Retrospective analysis of 417 COVID-19 patients' clinical records and lab results.
  • Data collected from a referral hospital in Shenzhen, China.
  • Focus on patients with abnormal liver tests and liver injury.

Main Results:

  • 76.3% of COVID-19 patients had abnormal liver tests; 21.5% had liver injury.
  • Abnormalities in ALT, AST, bilirubin, and GGT increased during hospitalization.
  • Hepatocellular/mixed type liver tests and lopinavir/ritonavir use correlated with severe disease and liver injury.

Conclusions:

  • Abnormal liver tests in COVID-19 patients are linked to a higher risk of severe disease.
  • Certain medications, like lopinavir/ritonavir, may contribute to liver injury.
  • Frequent monitoring of liver function and medication effects is crucial for COVID-19 patients.