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Hendersonula toruloidea infection in Thailand.
R Kotrajaras1, S Chongsathien, V Rojanavanich
1Institute of Dermatology, Bangkok, Thailand.
International Journal of Dermatology
|July 1, 1988
Summary
Hendersonula toruloidea causes tinea pedis in Thailand, with slow-growing strains and positive skin tests. Antifungal treatments show limited efficacy, indicating a need for further research into infection mechanisms.
Area of Science:
- Mycology
- Dermatology
- Infectious Diseases
Background:
- Hendersonula toruloidea is a fungal pathogen causing skin infections.
- Tinea pedis is a common fungal infection of the feet.
Purpose of the Study:
- To investigate the clinical presentation and treatment outcomes of Hendersonula toruloidea infections in Thailand.
- To characterize the growth patterns and antifungal susceptibility of H. toruloidea isolates.
Main Methods:
- Clinical data collection on tinea pedis patients.
- Microbiological isolation and identification of H. toruloidea.
- Antifungal sensitivity testing (Griseofulvin).
- Skin testing with H. toruloidea antigen.
Main Results:
- Scales (61%), erythema (22%), maceration (10.8%), and hyperkeratosis (9%) were key clinical features.
- Slow-growing H. toruloidea was more prevalent (2.8:1 ratio).
- Griseofulvin Minimum Inhibitory Concentration (MIC) exceeded 100 µg/ml for most isolates.
- Topical treatment with half-strength Whitfield ointment showed a low cure rate (0.02%).
Conclusions:
- Hendersonula toruloidea infection presents with diverse clinical signs in Thailand.
- Current antifungal therapies demonstrate limited effectiveness against this pathogen.
- Further research into the pathomechanism of H. toruloidea is warranted.