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Measuring functional limitations after venous thromboembolism: Optimization of the Post-VTE Functional Status (PVFS)
G J A M Boon1, S Barco2, L Bertoletti3
1Department of Medicine - Thrombosis and Hemostasis, Leiden University Medical Center, Leiden, the Netherlands.
Thrombosis Research
|April 17, 2020
Summary
The post-VTE functional status (PVFS) scale was refined with expert and patient input, improving its assessment of functional limitations after venous thromboembolism (VTE). This enhanced scale shows good-to-excellent agreement for measuring VTE recovery.
Area of Science:
- Medical research
- Clinical assessment tools
- Patient-reported outcomes
Background:
- Venous thromboembolism (VTE) can cause significant functional limitations.
- A previously proposed Post-VTE Functional Status (PVFS) scale requires further development.
- Assessing patient-relevant functional limitations is crucial for VTE management.
Purpose of the Study:
- To refine the PVFS scale based on expert and patient feedback.
- To achieve broad consensus on the use and assessment methods of the PVFS scale.
- To improve the evaluation of functional status following VTE.
Main Methods:
- A Delphi analysis involving 53 international VTE experts.
- Focus groups with 18 VTE patients to gather feedback.
- Refinement of scale grades, descriptions, and assessment procedures.
- Statistical analysis of interobserver agreement using κ-statistics.
Main Results:
- Reduced and improved PVFS scale grades with expert consensus.
- Patient focus groups confirmed scale relevance and suggested manual improvements.
- Good-to-excellent interobserver agreement (κ=0.75-1.0) for PVFS scale assessment.
- Consensus reached on scale's optimal grades and assessment methods.
Conclusions:
- The refined PVFS scale demonstrates broad consensus among experts and patients.
- The scale shows good-to-excellent reliability for assessing functional impairment after VTE.
- The PVFS scale is a valuable tool for VTE patient care quality and clinical trials.
Keywords:
Chronic thromboembolic pulmonary hypertensionClassificationDeep vein thrombosisFunctional limitationOutcomePatient engagementPost thrombotic syndromePulmonary embolismQuality of lifeVenous thromboembolismMore Related Videos
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