Mythical metrics and methods: Needed paradigm shift in disease recognition and therapy

Area of Science:

• Medical Science
• Anesthesiology
• Pathology

Background:

• Current medical practice is organ-centric, often oversimplifying organ perception and leading to diagnostic and therapeutic limitations.
• Technological advancements have not fundamentally altered this organ-based approach, resulting in evolving, resistant, and late-diagnosed diseases.
• Anesthesiology perspective highlights limitations in current diagnostic parameters, disease definitions, and treatment goals for conditions like cardiac disease.

Purpose of the Study:

• To challenge the fundamental organ-based paradigm in current medicine.
• To propose a new theoretical framework for disease understanding and diagnosis.
• To advocate for an upstream, tissue-level assessment approach utilizing advanced technology.

Main Methods:

• Critical review of current medical paradigms and practices, particularly in anesthesiology.
• Analysis of limitations in organ-based diagnosis, disease terminology, and treatment strategies.
• Development of a theoretical hypothesis for a structure-based tissue phenomenon model of disease.

Main Results:

• Identified significant limitations in the current organ-based medical model, leading to diagnostic delays and therapeutic challenges.
• Illustrated real-world examples where current medical 'myths' conflict with clinical 'reality'.
• Proposed a novel theoretical framework redefining disease as a structural tissue phenomenon.

Conclusions:

• The current organ-based medical paradigm is insufficient for addressing complex and evolving diseases.
• A shift towards an integrative, holistic, and structure-based tissue assessment is necessary.
• Redirecting technological innovation towards upstream, tissue-level analysis can redefine and enable early disease detection.