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Liposome-bound cyclosporine: clearance after intravitreal injection
A A Alghadyan1, G A Peyman, B Khoobehi
1LSU Eye Center, Louisiana State University Medical Center School of Medicine, New Orleans.
International Ophthalmology
|January 1, 1988
Abstract:
The concentration of cyclosporine in the vitreous after intravitreal injection of 100 micrograms of either free or liposome-bound cyclosporine was studied in albino rabbits. We found that the half-life of free cyclosporine was about 6 hours and that of liposome-bound cyclosporine was about 3 days. The finding indicates that liposome-bound cyclosporine prolongs the availability of the drug.